Valrubicin

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For R&D use only.

Catalog NO.：A830920
CAS No. : 56124-62-0
Molecular Formula：C₃₄H₃₆F₃NO₁₃
Molecular Weight： 723.64

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	56124-62-0	Appearance	Red powder
Catalog Number	A830920	MDL Number	MFCD01939322
Molecular Formula	C₃₄H₃₆F₃NO₁₃	Molecular Weight	723.64
Boiling Point		Melting Point
Flash Point		Density
Synonyms	[2-Oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302;H315;H319;H335	Class
Precautionary Statements	P261;P305+P351+P338	Packing Group

Description

Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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